November 26, 2018

KETOASIDOSIS DIABETIK PDF

Diabetic ketoacidosis (DKA) is a potentially life-threatening complication of diabetes mellitus. Signs and symptoms may include vomiting, abdominal pain, deep. 17 May Diabetic ketoacidosis (DKA) and hyperglycemic hyperosmolar state (HHS) are acute metabolic complications of diabetes mellitus that can. Diabetic ketoacidosis (DKA) and the hyperosmolar hyperglycemic state (HHS) are the two most serious acute metabolic complications of diabetes. DKA is.

Author: Yogore Gulmaran
Country: Bahrain
Language: English (Spanish)
Genre: Politics
Published (Last): 10 July 2016
Pages: 273
PDF File Size: 1.84 Mb
ePub File Size: 7.3 Mb
ISBN: 992-1-21658-807-2
Downloads: 16128
Price: Free* [*Free Regsitration Required]
Uploader: Telabar

The initial laboratory evaluation of patients include determination of plasma glucose, blood urea nitrogen, creatinine, electrolytes with calculated anion gaposmolality, serum and urinary ketones, and urinalysis, as well as initial arterial blood gases and a complete blood count with a differential.

Failure of adjunctive bicarbonate to improve outcome in severe pediatric diabetic ketoacidosis. This article has been cited by other articles in PMC. Neurological deterioration doabetik lead ektoasidosis seizures, incontinence, pupillary changes, bradycardia, and respiratory arrest.

Am J Med Sci ; Many of the underlying pathophysiologic disturbances in DKA are directly measurable by the clinician and need to be monitored throughout the course of treatment. Considering DKA and HHS as potentially fatal and economically burdensome complications of diabetes, every effort for ketoasiddosis the possible diaabetik factors is worthwhile. Am J Med ; Diabetic ketoacidosis secondary to dento-alveolar infection. Medicine Baltimore ; Drugs such as corticosteroids, thiazide diuretics, sympathomimetic agents e.

Drugs in the gliflozin class SGLT2 inhibitorswhich are generally used for type 2 diabetes, have been associated with cases of diabetic ketoacidosis where the blood sugars are not significantly elevated “euglycemic DKA”.

TOP Related  BUCKMINSTER FULLER GRUNCH OF GIANTS PDF

Hyperglycemic Crises in Adult Patients With Diabetes

Correction of fluid loss makes the clinical picture clearer ketoasdiosis may be sufficient to correct acidosis. Prospective randomized studies have failed to show any beneficial effect of phosphate replacement on the clinical outcome in DKA 4667and overzealous phosphate therapy can cause severe hypocalcemia 46 Several cultural and socioeconomic barriers, such as low literacy rate, limited financial resources, and limited access to health care, in medically indigent ketoasiosis may explain the lack of compliance and why DKA continues to occur in such high rates in inner-city patients.

Ketoacidosis occurring in newly diagnosed and established diabetic children.

The admission serum sodium is usually low because of the osmotic flux of water from the intracellular to the extracellular space in the presence of hyperglycemia. Sodium also is lost in the urine during the osmotic diuresis.

The origin of amylase in DKA is usually non-pancreatic tissue such as the parotid gland Prevention of hypophosphatemia by phosphate infusion during treatment of diabetic ketoacidosis and hyperosmolar coma.

The Journal of pediatrics ; Short-term fasting is a mechanism for the development of euglycemic ketoacidosis during periods of insulin deficiency.

Diabetic ketoacidosis

This increases the risk of dangerous irregularities in the heart rate. Patients must be advised to continue insulin and to seek professional advice early in the course of the illness.

Pitfalls of Laboratory Tests and Diagnostic Considerations for Interpreting Acid Base Status in DKA False positive values for lipase may be seen if plasma glycerol levels are very high due ketiasidosis rapid breakdown of adipose tissue triglycerides glycerol is the product measured in most assays for plasma lipase. GLC determination of serum-ethylene glycol, interferences in ketotic patients.

TOP Related  DESCARGAR LIBRO DE FISICA GENERAL DE HECTOR PEREZ MONTIEL PDF

Pembrolizumab versus Ipilimumab in Advanced Melanoma. Ketone bodies have generally included acetone, beta-hydroxybutyrate, and acetoacetate. Cerebral edema is a serious, major complication that may evolve at any time during treatment of DKA and primarily affects children. Am J Med ; Mental status can vary from full alertness to profound lethargy or coma, with the latter more frequent in Keetoasidosis.

Nine small studies in a total of patients with diabetic ketoacidosis treated with bicarbonate and patients without alkali therapy [ 62 ] support the notion that bicarbonate therapy for DKA offers no advantage in improving cardiac or neurologic functions or in the rate of recovery of hyperglycemia and ketoacidosis.

Diabetic ketoacidosis – Wikipedia

Int J Oral Maxillofac Surg. There is krtoasidosis evidence to support this. Potassium can be given as follows: Adapted from Kitabchi et al. Predisposing factors for the diabetic hyperosmolar state. It is the leading cause of DKA mortality in children. A soluble insulin is normally used with the aim of permitting more rapid titration of circulating insulin levels though there are no trial data comparing soluble against other types of insulin.

Differences in metabolic and hormonal milieu in diabetic- and alcohol-induced ketoacidosis.

High prevalence of glucosephosphate dehydrogenase deficiency without gene mutation suggests a novel genetic mechanism predisposing to ketosis-prone diabetes.